Gallery of Biomolecule Simulations
Breathing (gating) of the channel to the active site of
acetylcholinesterase. The gating contributes to the specificity of action
of the enzyme (``dynamic selectivity'') by greatly slowing the binding of
substrates that are larger than the natural one.
Zhou, H.-X., S.T. Wlodek, J.A. McCammon. Conformation Gating as a
Mechanism for Enzyme Specificity. Proc.
Natl. Acad. Sci. USA 95, 9280-9283 (1998).
McCammon Group, UCSD -
http://mccammon.ucsd.edu/ -
created by Kaihsu Tai
