Gallery of Biomolecular Simulations

Ribosome Motions Modulate Electrostatic Properties

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The changes in the electrostatic potential of the 70S ribosome occurring during the ratchet-like motion [1,2]. Potential was obtained by solving the Poisson-Boltzmann equation with the Adaptive Poisson-Boltzmann Solver [3], for various backbone structures of the ribosome derived from normal mode analysis. Red color denotes potential isosurface of -5kT/e and blue +1kT/e.

[1] F. Tama, M. Valle, J. Frank and C. L. Brooks III, Proc. Natl. Acad. Sci. USA , 2003, 100, 9319

[2] J. Trylska, R. Konecny, F. Tama, C. L. Brooks III, and J. A. McCammon Biopolymers, 2004, 74, 423

[3] N. A. Baker, D. Sept, S. Joseph, M. J. Holst and J. A. McCammon, Proc. Natl. Acad. Sci. USA, 2001, 98, 10037

For more information on the ribosome work described here, please contact Joanna Trylska.

McCammon Group, UCSD (http://mccammon.ucsd.edu/)
Created by Cameron Mura on Wed Sep 3 19:45:43 PDT 2003.
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