![[ Breathing of the channel ]](003.gif)
Breathing (gating) of the channel to the active site of acetylcholinesterase. The gating contributes to the specificity of action of the enzyme ("dynamic selectivity") by greatly slowing the binding of substrates that are larger than the natural one.
Zhou, H.-X., S.T. Wlodek, & J.A. McCammon. "Conformation Gating as a Mechanism for Enzyme Specificity".
Proc. Natl. Acad. Sci. USA. 95, 9280-9283 (1998).
McCammon Group, UCSD (http://mccammon.ucsd.edu/)
Created by Cameron Mura on Sat Jun 7 17:55:12 PDT 2003.
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